Which beta-lactam antibiotic has MRSA activity?

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Multiple Choice

Which beta-lactam antibiotic has MRSA activity?

Explanation:
MRSA resistance to most beta-lactams comes from altered PBPs, especially PBP2a, which reduces drug binding and blocks inhibition of cell wall synthesis. Ceftaroline, a fifth-generation cephalosporin, binds PBP2a with high affinity, allowing it to inhibit cell wall synthesis in MRSA strains. That unique binding gives it activity against MRSA within the beta-lactam class. The other options aren’t beta-lactams or don’t target the cell wall in the same way: vancomycin is a glycopeptide, linezolid and doxycycline inhibit protein synthesis. So ceftaroline is the beta-lactam that retains MRSA activity.

MRSA resistance to most beta-lactams comes from altered PBPs, especially PBP2a, which reduces drug binding and blocks inhibition of cell wall synthesis. Ceftaroline, a fifth-generation cephalosporin, binds PBP2a with high affinity, allowing it to inhibit cell wall synthesis in MRSA strains. That unique binding gives it activity against MRSA within the beta-lactam class. The other options aren’t beta-lactams or don’t target the cell wall in the same way: vancomycin is a glycopeptide, linezolid and doxycycline inhibit protein synthesis. So ceftaroline is the beta-lactam that retains MRSA activity.

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