What is the current name for Churg-Strauss?

• A. Eosinophilic granulomatosis with polyangiitis
• B. Granulomatosis with polyangiitis
• C. Microscopic polyangiitis
• D. Goodpasture syndrome

Answer: (B)

Churg-Strauss syndrome is now called eosinophilic granulomatosis with polyangiitis, or EGPA. This name reflects the disease’s defining features: eosinophil-rich granulomatous inflammation with vasculitis of small- to medium-sized vessels, typically in patients with a history of asthma and allergic symptoms, often with peripheral eosinophilia. It’s part of the group of ANCA-associated vasculitides, commonly linked to MPO-ANCA (p-ANCA) positivity. The other conditions listed are different diseases within the same broad category: granulomatosis with polyangiitis (GPA) is Wegener’s, focused on granulomatous inflammation of the respiratory tract and kidneys; microscopic polyangiitis (MPA) is a pauci-immune vasculitis without granulomas; Goodpasture syndrome is anti-GBM disease causing pulmonary hemorrhage and glomerulonephritis. So the current name for Churg-Strauss is eosinophilic granulomatosis with polyangiitis.